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Dr. Seema Sehrawat is an accomplished Senior Scientist and Associate professor with 10 years of research experience from Harvard Medical School, Boston, USA with research focus in Biomedical Engineering. She heads a Brain Metastasis and NeuroVascular Disease Modeling Lab at one of the leading research focused private universities in India, Shiv Nadar University.

She has been trained as a Post-Doctoral Fellow at the Center for Excellence in Vascular Biology, Brigham and Women’s Hospital, Boston, MA, USA. She worked on Vascular Dysfunction and the role of cAMP-Epac1-AKAP9 dependent Endothelial Barrier Regulation by integrating Microtubule Dynamics, Microfluidics based Chips and Platforms & Cell Signaling Analysis for Biomedical Applications. Her education includes a Ph.D. from the prestigious Indian Institute of Science, Bangalore, India. Her major research interests during the graduate program were in Baculovirus Transcription and the potential application of Baculovirus Expression Vector System as Gene Therapy Vehicles for Biotherapeutics & Biomedical Applications.

Scientific Advisor at Sporos Therapeutics, a biotechnology company focused on innovative futuristic medicines for solving unmet medical needs. The company focus is centered on the development of Best-in-class approaches to solve the challenges associated with Vaccine Delivery, Next Generation Adjuvants, and Cancer BioTherapeutics. Recently completed her pre-MBA, CORe (6 months) with emphasis on Business Analytics, Financial Accounting and Economics for Managers from Harvard Business School, Boston, MA, USA. Completed the preliminary Regulatory Affairs Essentials Certificate Program from University of California San Diego, School of Extended Studies and Public Program.

Her current research interest: Combination Therapy for Breast Cancer associated Brain Metastasis and Tumor Angiogenesis with special focus on Adenosine signalling and PD-L1 targeting therapeutics; NeuroVascular Disease Modeling in 3D using Electric Cell-substrate Impedance Sensing based Microfluidic Platforms and Chips, 3D Bioprinted platforms and devices for CRISPR/CAS9 based Genome Editing in Brain Stroke treatment, Cancer Immunotherapy check point regulators and Nanomedicine based therapy. She has published her research work in high impact journals like Nature Communications, Blood, PNAS, Molecular Biology of the Cell, Journal of Immunology, Biochemical Journal, Molecular and Cellular Biochemistry, Gene and Organic and Biomolecular Chemistry and Stem Cells Reports.

She has obtained the following independent Research funding and grants:

Bio-CARe AWARD, Department of Biotechnology, Government of IndiaTotal Budget-50 lakhs (~80,000 dollars) as Principal Investigator. Functional dissection of cAMP regulated AKAP9 in Vascular dysfunction: Strategy for treatment of Breast Cancer, 2014-2017, Extendable until 2019 with additional budget.

Multidisciplinary Collaborative grant with Dr. Debopam Acharya (PI), Department of Computer Science, SNU; IIIT New Delhi and IGDTUW. Funded by Information Technology Research Academy ITRA, Department of Electronics and Information Technology, Govt. Of India  (DeitY): Total Budget ~ 2.6 crores (~400,000 dollars) as Co-Investigator. HumanSense: Towards context aware sensing, inference and actuation for applications in Energy and Healthcare2013-17

SELECT PUBLICATIONS

  1. Naveen Kumarǂ, Sonal Guptaǂ, Surbhi Dabral, Shailja Singh*, Seema Sehrawat* (2017). Role of Exchange Protein directly activated by cAMP (EPAC 1) in Breast cancer cell migration and Apoptosis. Molecular and Cellular Biochemistry, Feb 16. doi: 10.1007/s11010-017-2959-3
  2. Kalai Mangai Muthukumarasamy,   Kishor L Handore,  Dipti N Kakade,   Madhuri Vikas Shinde,   Shashi Ranjan,  Naveen Kumar,   Seema Sehrawat,   Chetana Sachidanandanand  D SRINIVASA REDDY (2016).  Identification of noreremophilane-based inhibitors of angiogenesis using zebrafish assays. Biomol. Chem., Feb 7;14(5):1569-78. [Impact factor 3.6].
  3. Yamicia Connor, Sarah Tekleab, Shyama Nandakumar, Cherelle Walls, Yonatan Tekleabr, Amjad Husain, Or Gadish, Venkata Sabbisetti, Shelley Kaushik, Seema Sehrawat, Ashish Kulkarni, Harold Dvorak, Elazer Edelman, Bruce Zetter, Shiladitya Sengupta (2015). Physical nanoscale conduits-mediated communication between tumor cells and endothelium enables a metastatic hijack. Nature Communications, December 16; 6: 8671. [Impact factor 11.47].
  4. Lakshmi Kannan, Katalin Kis-Toth, Kazuhisa Yoshiya, Sehrawat S, Jurandir J. Dalle Lucca, To-Ha Thai, Tanya Mayadas, George C. Tsokos (2013). R-spondin3 protects intestinal tissue from ischemia/reperfusion-induced injury by tightening endothelial cell junctions and preventing vascular leakage. Proc Natl Acad Sci U S A. 2013 Aug 27;110 (35):14348-53 [Impact factor 9.73].
  5. William James Adams, Yuzhi Zhang, Jennifer Cloutier, Pranati Kuchimanchi, Gail Newton, Sehrawat S, William Cameron Aird, Tanya Mayadas Norton, Francis William Luscinskas, and Guillermo García-Cardeña (2013). Generation and Specification of Functional Human Vascular Endothelium Derived from Induced Pluripotent Stem Cells. Published in the inaugural Issue of “Stem Cell Reports” 1, 105–113, August 6. [Impact factor 7.03].
  6. Sehrawat S, Ernandez T, Cullere X , Komarova Y, Mayadas TN. (2011). AKAP9 regulation of microtubule dynamics promotes Epac1 induced endothelial integrin adhesion at cell-cell contacts. Blood, 117(2):708-18. [Impact factor: 11.84]
  7. Alcaide P, Newton G, Auerbach S, Sehrawat S, Mayadas TN, Golan DE, Yacono P, Vincent P, Kowalczyk A, Luscinskas FW. (2008). p120-Catenin regulates leukocyte transmigration through an effect on VE-cadherin phosphorylation. Blood. 112(7):2770-9. [Impact factor: 11.84]
  8. Sehrawat S, Cullere X, Patel S, Italiano J Jr, Mayadas TN. (2008). Role of Epac1, an exchange factor for Rap GTPases, in endothelial microtubule dynamics and barrier function. Mol Biol Cell. 19(3):1261-70. [Impact factor: 5]
  9. Sircar M, Bradfield PF, Aurrand-Lions M, Fish RJ, Alcaide P, Yang L, Newton G, Lamont D, Sehrawat S, Mayadas T, Liang TW, Parkos CA, Imhof BA, Luscinskas FW. (2007). Neutrophil transmigration under shear flow conditions in vitro is junctional adhesion molecule-C independent. J Immunol. 178(9):5879-87. [Impact factor: 5]
  10. Sehrawat S, and Gopinathan, K. P. (2002). Temporal expression profile of late gene expression 4 from Bombyx mori nucleopolyhedrosis virus. Gene 294, 67-75. [Impact factor: 2.34]
  11. Sehrawat S, Srinivasan, N. and Gopinathan, K. P. (2002). Functional characterization and structural modeling of late gene expression factor 4 from Bombyx mori nucleopolyhedrosis virus. J. 368, 159-169. [Impact factor: 5]
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